Overnight maintenance begins over the weekend on the eastbound and westbound Route-54 Missouri River bridges in Jefferson City.
MoDOT says, during the work, one bridge at a time will be reduced to a single lane of traffic.
Crews will also close the entrance ramps from McCarty Street and Main Street to eastbound-54, as well as the entrance ramp from Route-W to westbound-54.
The work is scheduled to be done between 6:30pm and 5am with signage in place telling motorists where they can go.
The work is weather permitting and could be delayed.